Thiamphenicol

  • Thiocymetin
  • Dextrosulphenidol
  • Methylsulfonylchloramphenicol
  • D-threo-2,2-Dichloro-N-(b-hydroxy-a-[hydroxymethyl]-4-[methylsulfonyl]phenethyl)acetamide
Formula
C12H15Cl2NO5S
Structure
Uses
Veterinary antimicrobial agent.

Registry Numbers and Inventories.
CAS
15318-45-3
EC (EINECS/ELINCS)
239-355-3
22 24/25
RTECS
AB6680000
RTECS class
Reproductive Effector; Human Data
Merck
12,9436
Beilstein/Gmelin
2819542
Beilstein Reference
4-13-00-02957
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C12H15Cl2NO5S
Formula mass
356.23
Melting point, °C
165 - 166
Vapor pressure, mmHg
3E-20 (25 C)
Density
1.55 g/cm3
Solubility in water
Slightly soluble
pKa/pKb
11.05 (pKa)
Partition coefficient, pKow
-0.38
Heat of vaporization
107.0 kJ/mol

Hazards and Protection.
Protection
Compatible chemical-resistant gloves. Chemical safety goggles.
Respirators
Government approved respirator.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Decomposition
Carbon monoxide, Carbon dioxide, Nitrogen oxides, Sulfur oxides, Hydrogen chloride gas.

Fire.
Fire fighting
Extinguish using Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.

Health.
Exposure effects
Avoid contact and inhalation. Target organ(s): Bone marrow.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.