Thiamylal

  • 4,6(1H,5H)-Pyrimidinedione, dihydro-5-(1-methylbutyl)-5-(2-propenyl)-2-thioxo
  • 5-Allyl-5-(1-methylbutyl)-2-thiobarbituric acid
  • Thioseconal
  • Bio-Tal
Formula
C12H18N2O2S
Structure
Uses
Intravenous anesthetic. USDEA Schedule III.

Registry Numbers and Inventories.
CAS
77-27-0
EC (EINECS/ELINCS)
201-018-3
23/24/25
36/37/39 45
UN (DOT)
2811
Merck
12,9437
Japan ENCS (MITI)
Listed

Properties.
Formula
C12H18N2O2S
Formula mass
254.35
Melting point, °C
139
Boiling point, °C
494
Density
1.16 g/cm3 (20 C)
Solubility in water
81 mg/L (25 C)
pKa/pKb
7.66 (pKa)
Partition coefficient, pKow
3.14

Hazards and Protection.
Protection
Compatible chemical-resistant gloves. Chemical safety goggles. Protective clothing.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and presures.
Incompatibilities
Avoid contact with buffers and bacteriostatic agents.
Decomposition
Carbon monoxide, Carbon dioxide, Nitrogen oxides, Sulfur oxides.

Fire.
Fire fighting
Extinguish with water spray, carbon dioxide, dry chemical powder or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.
Health
2
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Harmful if swallowed, inhaled, or absorbed through skin. May cause irritation. Exposure can cause headache, drowsiness, confusion, amnesia, and cardiac arrhythmias. Prolonged or repeated exposure can lead to habituation or addiction.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
   Skin
In case of contact, immediately wash skin with soap and copious amounts of water. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.
UN number
2811
Response guide
Hazard class
6.1
Packing Group
III