Thioridazine

  • Mallorol
  • Malloryl
  • Meleril
  • Mellaril
  • Mellerets
  • Mellerette
Formula
C21H26N2S2 . HCl
Structure
Description
Off white, aqueous suspension with a peppermint odor.
Uses
antipsychotic drug

Registry Numbers and Inventories.
CAS
130-61-0
EC (EINECS/ELINCS)
204-992-8
RTECS
SP2100000
RTECS class
Drug; Mutagen; Human Data
Merck
12,9497
Beilstein/Gmelin
4170703
Beilstein Reference
4-27-00-02050
Austrailia AICS
Listed
New Zealand
Listed
Korea ECL
Listed

Properties.
Formula
C21H26N2S2.ClH
Formula mass
407.04
Melting point, °C
158 - 160
Boiling point, °C
230 (0.02 torr)
Vapor pressure, mmHg
1E-12
Solubility in water
soluble
pKa/pKb
4.50 (pKb)
Partition coefficient, pKow
5.90

Hazards and Protection.
Storage
Keep in a tightly closed, amber bottle in a cool (<20C) location.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Not required.
Small spills/leaks
Contain with an absorbent material and place in a closed container for disposal.
Stability
Stable in moderate heat, darkens on exposure to light.
Incompatibilities
Strong oxidizing agents.
Decomposition
Oxides of carbon, nitrogen and sulfur. Chlorine.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
May cause tardive dyskinesia, neuroleptic malignant syndrome, mild and transient drowsiness, dryness of the mouth, blurred vision and nausea.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.