Thiothixene

  • P-4657-b
  • N,N-Dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene) thioxanthene-2-sulfonamide
  • N,N-Dimethyl-9-[3-(4-methylpiperazin-1-yl)propylidene]-9H-thioxanthene-2-sulphonamide
  • Navan
  • Navane
  • Navaron
Formula
C23H29N3O2S2
Structure
Description
Red, thin, sticky syrup with a fruity odor.
Uses
Antipsychotic.

Registry Numbers and Inventories.
CAS
5591-45-7
EC (EINECS/ELINCS)
227-001-0
RTECS
XO1400000
RTECS class
Drug; Reproductive Effector; Human Data
Merck
12,9503
Beilstein/Gmelin
903138
Beilstein Reference
5-23-02-00520
New Zealand
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C23H29N3O2S2
Formula mass
443.63
Melting point, °C
147.5 - 149
Density
1.2 g/cm3 (20 C)
Solubility in water
practically insoluble
Partition coefficient, pKow
3.78

Hazards and Protection.
Storage
Store in a cool, dry, well-ventilated location. Keep container closed. Keep away from heat, light, industrial materials and poisons.
Handling
Avoid skin and eye contact. Do not inhale vapors/mists.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Not needed in normal service.
Small spills/leaks
Soak up material with non-combustible, inert adsorbant. Place collected material in an appropriate container for disposal. Clean spill area to remove slipperiness. Use protective equipment.
Stability
Unstable in light affected by light hydrochloride the constituted powder for injection is stable for 48 hr at room temperature.
Incompatibilities
Strong oxidizing agents.
Decomposition
Hydrogen chloride, oxides of nitrogen and sulfur.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
Chlorprothixene - respiratory depression and dyspnea may occur with overdose. Abnormally low blood pressure may develop after a delay of several hours and persist for up to three days. BREAST MILK - Flupenthixol is excreted in the breast milk.
   Ingestion
Respiratory depression may occur with overdose of thioxanthenes.
   Inhalation
Respiratory depression may occur with overdose of thioxanthenes.
   Skin
May cause irritation, allergic reation or photosensitivity.
   Eyes
Constricted pupils may occur with chlorprothixene overdose. However, comatose patients often present with fixed pupils.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.