Tibolone

  • 19-Norpregn-5(10)-en-20-yn-3-one, 17-hydroxy-7-methyl-, (7alpha,17alpha)
  • (7a,17a)-17-Hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one
  • 7a-Methyl-17a-ethynyl-17b-hydroxy-5(10)-estren-3-one
  • 7a-Methyl-D5,10-norethindrone
Formula
C21H28O2
Structure

Registry Numbers and Inventories.
CAS
5630-53-5
EC (EINECS/ELINCS)
227-069-1
Merck
12,9566

Properties.
Formula
C21H28O2
Formula mass
312.45
Melting point, °C
167
Boiling point, °C
447
Vapor pressure, mmHg
7.0E-10 (25 C)
Density
1.13 g/cm3 (20 C)
Solubility in water
Insoluble
pKa/pKb
13.10 (pKa)
Partition coefficient, pKow
4.03
Heat of vaporization
81.4 kJ/mol

Hazards and Protection.
Storage
Store in original container in a cool dark place.
Protection
Wear self-contained breathing apparatus, rubber boots & heavy rubber gloves.
Small spills/leaks
Sweep-up/absorb in suitable material, place in a container and hold for disposal. Avoid raising dust. Ventilate area and wash spill site after pickup is complete.

Fire.
Flash Point,°C
191
Fire fighting
Extinguish with carbon dioxide, dry chemical powder or appropriate foam. Water spray. Wear self-contained breathing apparatus and protective clothing to prevent contact with the skin and eyes.
Combustion products
Emits toxic fumes under fire conditions.

Health.
Exposure effects

First aid
 
   Ingestion
If swallowed, wash out mouth with water, provided person is conscious. Seek medical advice.
   Inhalation
Remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen. Seek medical attention.
   Skin
Immediately wash skin with soap and copious amounts of water for at least 15 minutes. If irritation persists, seek medical attention.
   Eyes
Immediately flush eyes with copious amounts of water for at least 15 minutes. Seek medical advice.

Transport.