Tirapazamine

  • 3-Amino-1,2,4-benzotriazine-1,4-dioxide
  • 1,2,4-Benzotriazin-3-amine, 1,4-dioxide
  • 1,2,4-Benzotriazine, 3-amino, 1,4-dioxide
  • SR-4233
  • WIN-59075
Formula
C7H6N4O2
Structure

Registry Numbers and Inventories.
CAS
27314-97-2
R: 36/37/38
S: 26 36
RTECS
DM0671500
Merck
12,10378
Beilstein/Gmelin
179322
Beilstein Reference
4-26-00-01120

Properties.
Formula
C7H6N4O2
Formula mass
178.15
Melting point, °C
220
Partition coefficient, pKow
-0.7

Hazards and Protection.
Storage
Store at 2-8 C.
Protection
Chemical-resistant gloves. Chemical safety goggles.
Respirators
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Where risk assessment shows air-purifying respirators are appropriate use a dust mask type N95 (US) or type P1 (EN 143) respirator.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, Carbon dioxide, Nitrogen oxides.

Fire.
Fire fighting
Extinguish using water spray, carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Combustion products
Emits toxic fumes under fire conditions.

Health.
Exposure effects
Material is irritating to mucous membranes and upper respiratory tract. May be harmful by inhalation, ingestion, or skin absorption. Causes eye and skin irritation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
   Skin
In case of contact, immediately wash skin with soap and copious amounts of water.
   Eyes
In case of contact, immediately flush eyes with copious amounts of water for at least 15 minutes.

Transport.