Tobramycin

  • Deoxykanamycin B
  • 3'-Deoxykanamycin B
  • Distobram
  • 1-Epitobramycin
  • Gernebcin
  • O-[3-Amino-3-deoxy-a-D-glucopyranosyl-(1®6)]-O-[2,6-diamino-2,3,6-trideoxy-a-D-ribohexopyranosyl-(1®4)]-2-deoxy-Dstreptamine
Formula
C18H37N5O9
Structure
Description
white solid
Uses
Irreversible inhibition of bacterial protein synthesis. Spectrum of Activity: Gram negative bacteria. Not effective against Enterococci.

Registry Numbers and Inventories.
CAS
32986-56-4
EC (EINECS/ELINCS)
251-322-5
RTECS
WK2100000
RTECS class
Drug; Mutagen; Reproductive Effector; Human Data; Natural Product
UN (DOT)
1544
Merck
12,9628
Beilstein/Gmelin
1357507
Beilstein Reference
6-18
Canada DSL/NDSL
DSL
New Zealand
Listed
Korea ECL
Listed

Properties.
Formula
C18H37N5O9
Formula mass
467.52
Melting point, °C
168 - 178
Vapor pressure, mmHg
9E-28 (25 C)
Solubility in water
Very soluble
pKa/pKb
13.07 (pKa)
Heat of vaporization
128.7 kJ/mol

Hazards and Protection.
Storage
Keep tightly closed. Store at -20 C
Protection
Compatible chemical-resistant gloves.
Respirators
Government approved respirator.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, Carbon dioxide, Nitrogen oxides.

Fire.
Flash Point,°C
423
Fire fighting
Extinguish using Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Fire potential
Non-Combustible
Hazards
Emits toxic fumes under fire conditions.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
2
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Properties of this material have not yet been prepared. Any recommendations are of a general nature. Many chemicals cause irritation of the eyes, skin, and respiratory tract. In severe cases respiratory tract irritation can progress to ARDS/acute lung injury which may be delayed in onset for up to 24 to 72 hours in some cases Irritation or burns of the esophagus or gastrointestinal tract are also possible if caustic or irritant chemicals are ingested. ALWAYS contact your local poision control authority or medical professional for assistance.
   Ingestion
Toxic if swallowed.
   Inhalation
May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.
   Skin
May cause skin irritation. May be harmful if absorbed through the skin.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician immediately.
   Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.
UN number
1544
Response guide
Hazard class
6.1
Packing Group
II