Tolazamide

  • Tolinase
  • 1-(Hexahydro-1-azepinyl)-3-p-tolylsulfonylurea
  • 1-(4-Methylphenylsulfonyl)-3-(hexahydro-1H-azepin-1-yl)urea
  • Benzenesulfonamide, N-[[(hexahydro-1H-azepin-1-yl)amino]carbonyl]-4-methyl-
Formula
C14H21N3O3S
Structure
Description
White to off-white crystalline powder. Odorless or with a slight odor.
Uses
Therap cat: antidiabetic.

Registry Numbers and Inventories.
CAS
1156-19-0
EC (EINECS/ELINCS)
214-588-3
RTECS
YT4400000
RTECS class
Tumorigen; Drug; Mutagen; Human Data
Merck
12,9644
Beilstein/Gmelin
1323565
Beilstein Reference
5-20-04-00062
Austrailia AICS
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C14H21N3O3S
Formula mass
311.41
Melting point, °C
168 - 171
Solubility in water
Slightly soluble
Partition coefficient, pKow
1.71

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter.
Small spills/leaks
If a spill of this chemical occurs, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with acetone and transfer the dampened material to a suitable container. Use absorbent paper dampened with acetone to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with acetone followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Stability
No data.
Incompatibilities
Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents Can react as acids Incompatible with acids.

Fire.
Fire fighting
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.
Fire potential
This material is probably combustible.

Health.
Exposure effects
   Ingestion
See inhalation.
   Inhalation
Symptoms of exposure to this compound may include nausea, vomiting, epigastric pain, dizziness, weakness, paresthesia, sensitivity reactions such as fever, eosinophilia, jaundice and skin rashes, blood disorders such as leukopenia, thrombocytopenia, aplastic anemia and agranulocytosis, and intolerance to alcohol (with facial flushing). Hypoglycemia can also occur. Hematological disorders include pancytopenia and hemolytic anemia. Photosensitivity, hemorrhage, increased serum alkaline phosphatase and cholestatic jaundice have been reported. Other symptoms may include heartburn, fatigue, malaise and allergic skin reactions which include pruritis, erythema, urticaria and morbilliform or maculopapular eruptions.
   Skin
See inhalation.
   Eyes
See inhalation

First aid
 
   Ingestion
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Transport.