Tolbutamide

  • Aglicid
  • Arkozal
  • Artosin
  • Artozin
  • Butamid
  • Butamide
Formula
C12H18N2O3S
Structure
Description
White crystals.
Uses
Therap cat: antidiabetic.

Registry Numbers and Inventories.
CAS
64-77-7
EC (EINECS/ELINCS)
200-594-3
RTECS
YS4550000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data
Merck
12,9646
Beilstein/Gmelin
1984428
Beilstein Reference
4-11-00-00396
Swiss Giftliste 1
G-9145
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C12H18N2O3S
Formula mass
270.35
Melting point, °C
127 - 128
Density
1.251 g/cm3
Solubility in water
Insoluble
Refractive index
1.5
pKa/pKb
5.16 (pKa)
Partition coefficient, pKow
2.34
Heat of fusion
24.7 kJ/mol

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter.
Small spills/leaks
If a spill of this chemical occurs, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with acetone and transfer the dampened material to a suitable container. Use absorbent paper dampened with acetone to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with acetone followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Stability
No data.
Incompatibilities
Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents Can react as acids Incompatible with acids.

Fire.
Fire fighting
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.
Fire potential
This material is probably combustible.

Health.
Poison_Class
4
Exposure effects
hypoglycemia may cause dizziness, weakness, paresthesia, headache, lethargy, seizures, coma, alteration in consciousness or neuropsychiatric symptoms.
   Ingestion
Nausea, vomiting, and epigastric pain may occur or overdose.
   Inhalation
Symptoms of exposure to this chemical may include aplastic anemia, hypoglycemia, nausea, vomiting, weakness, intolerance to alcohol, skin eruptions, and rarely, leukopenia, thrombocytopenia, thyroid suppression, hyperlipemia or gastrointestinal bleeding from ulcers.
   Skin
See inhalation.
   Eyes
See inhalation

First aid
 
   Ingestion
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. If symptoms (such as redness or irritation) develop, immediately transport the victim to a hospital.

Transport.