Tolmetin

  • McN 2559
  • Tolectin
  • Tolmetine
  • 1-Methyl-5-p-toluoylpyrrole-2-acetic acid
  • 5-[(p-Tolyl)carbonyl]-1-methylpyrrole-2-acetic acid
  • 1H-Pyrrole-2-acetic acid, 1-methyl-5-(4-methylbenzoyl)-
Formula
C15H15NO3
Structure
Description
crystals from acetonitrile.
Uses
Medication.

Registry Numbers and Inventories.
CAS
26171-23-3
EC (EINECS/ELINCS)
247-497-2
RTECS
UX9287000
RTECS class
Drug; Reproductive Effector
Merck
12,9655
Beilstein/Gmelin
485305
Beilstein Reference
5-22-06-00392
Austrailia AICS
Listed

Properties.
Formula
C15H15NO3
Formula mass
257.29
Melting point, °C
191
Solubility in water
Soluble
pKa/pKb
4.46 (pKa)
Partition coefficient, pKow
2.79

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
No data.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
Low grade fever, abnormally low blood pressure, and sinus rapid heart rate have been noted in both overdose and therapeutic use of nsaids. drowsiness, delirium, lethargy, seizures, dizziness, disorientation, loss of consciousness, tinnitus, headache, hallucinations and encephalopathy have been associated with therapeutic dosing and/or overdose of non-steroidal anti-inflammatory drugs. Coma has been reported following severe nsaid overdose. Myoclonic twitching as been reported for several days after an overdose of piroxicam and fentiazac. Use in pregnancy is not recommended. Inhibition of prostaglandin synthesis may cause closure of the ductus arteriosus. NSAIDs may prolong pregnancy if taken before the onset of labor, especially during the third trimester.
   Ingestion
Nausea, vomiting, epigastric pain, erosive esophagitis, pancreatitis, gastrointestinal bleeding, and intestinal stenosis have been associated and/or overdose of non-steroidal antiinflammatory drugs.
   Inhalation
Although rare, respiratory arrest has been reported. Pulmonary fibrosis has been associated .
   Skin
Photosensitivity, toxic epidermal necrolysis, erythema multiforme, and phototoxicity have been reported .
   Eyes
Various ocular adverse reactions and tinnitus are frequently reported following NSAID overdoses. Bullous and erosive stomatitis has occurred in a patient taking nimesulide and diclofenac.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.