- 4-Methyl-m-phenylene diisocyanate
Water white to pale yellow liquid or crystals with a sweet, fruity, pungent odor. Darkens on exposure to sunlight.
Registry Numbers and Inventories.
EC Index Number
Carcinogenic Category 3; Very toxic; Irritant; Sensitising; Dangerous for the Environment
R 26 36/37/38 40 42/43 52/53
S 23 36/37 45 61
Tumorigen; Mutagen; Human Data; Primary Irritant
Swiss Giftliste 1
Japan ENCS (MITI)
Melting point, °C
Boiling point, °C
Vapor pressure, mmHg
0.008 (25 C)
33 ppm (25 C)
Odor Threshold Odor threshold 0.4-2.14 ppm
1.218 g/cm3 (20 C)
Solubility in water
0.0027 cp (25 C)
1.5678 (20 C)
2.52 D (20 C)
Heat of vaporization
Heat of combustion
Hazards and Protection.
Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from moisture. Store under an inert atmosphere.
D1A D2A D2B
Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Avoid breathing dust, vapor, mist, or gas. Do not allow contact with water.
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions.
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Avoid runoff into storm sewers and ditches which lead to waterways. Provide ventilation. Do not expose spill to water. Do not get water inside containers.
Stable under normal temperatures and pressures.
Alcohols - strong bases - amines - acids - heat - light - strong oxidizing agents - moisture.
Hydrogen cyanide, nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.
Upper exp. limit, %
Lower exp. limit, %
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Containers may explode in the heat of a fire. Extinguishing media: For large fires, use water spray or fog. Do NOT get water inside containers. Do NOT use straight streams of water. Cool containers with flooding quantities of water until well after fire is out. For small fires, use dry chemical or carbon dioxide.
Slightly flammable. Combustible when exposed to heat or flame.
When heated to decomposition it emits very toxic fumes of cyanide and nitrogen oxides. Reacts violently with amines, alcohol, bases and warm water causing fire and explosion hazards. Avoid strong oxidizers, water, acids, bases, amines, etc., cause foam and splatter. Avoid heating. Hazardous polymerization may occur. Concentrated alkaline compound such as sodium hydroxide or tertiary amines may cause run-away polymerization. Slow, not hazardous polymerization may occur above 235F.
Toxic oxides of nitrogen are produced during combustion of this material.
NIOSH REL: Ca See Appendix A OSHA PEL: C 0.02 ppm (0.14 mg/m3) IDLH Ca [2.5 ppm]
Acute exposures may produce headache, insomnia, euphoria, ataxia, anxiety neurosis with depression, paranoid tendencies, or impotence. No data were available to assess the teratogenic potential of this agent. <br>No data were available to assess the potential effects of exposure to this agent during pregnancy or lactation.
Causes gastrointestinal tract irritation.
May be fatal if inhaled. Causes respiratory tract irritation.
Causes skin irritation.
Causes eye irritation.
Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. DO NOT use mouth-to-mouth respiration.
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Get medical aid if symptoms occur.
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.