Toluene 2,4-diisocyanate

  • 2,4-Diisocyanatotoluene
  • 2,4-Tolyenediisocyanate
  • TDI
  • 4-Methyl-m-phenylene diisocyanate
  • 2,4-Diisocyanato-1-methylbenzene
Formula
2,4-(NCO)C6H3CH3
Structure
Description
Water white to pale yellow liquid or crystals with a sweet, fruity, pungent odor. Darkens on exposure to sunlight.
Uses
Chemical intermediate.

Registry Numbers and Inventories.
CAS
584-84-9
EC (EINECS/ELINCS)
209-544-5
EC Index Number
615-006-00-4
EC Class
Carcinogenic Category 3; Very toxic; Irritant; Sensitising; Dangerous for the Environment
R 26 36/37/38 40 42/43 52/53
S 23 36/37 45 61
RTECS
CZ6300000
RTECS class
Tumorigen; Mutagen; Human Data; Primary Irritant
UN (DOT)
2078
Merck
12,9668
Beilstein/Gmelin
744602
Beilstein Reference
4-13-00-00243
RCRA
U223
Swiss Giftliste 1
G-3610
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C9H6N2O2
Formula mass
174.16
Melting point, °C
21
Boiling point, °C
251
Vapor pressure, mmHg
0.008 (25 C)
Saturation Concentration
33 ppm (25 C)
Odor Threshold Odor threshold 0.4-2.14 ppm
Critical temperature
488
Critical pressure
29.5
Density
1.218 g/cm3 (20 C)
Solubility in water
Insoluble
Viscosity
0.0027 cp (25 C)
Surface tension
25 g/s2
Refractive index
1.5678 (20 C)
Dipole moment
2.52 D (20 C)
Heat of vaporization
40.61 kJ/mol
Heat of combustion
-4126 kJ/mol

Hazards and Protection.
Storage
Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from moisture. Store under an inert atmosphere.
D1A D2A D2B
Handling
Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Avoid breathing dust, vapor, mist, or gas. Do not allow contact with water.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Avoid runoff into storm sewers and ditches which lead to waterways. Provide ventilation. Do not expose spill to water. Do not get water inside containers.
Disposal code
9
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Alcohols - strong bases - amines - acids - heat - light - strong oxidizing agents - moisture.
Decomposition
Hydrogen cyanide, nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.

Fire.
Flash Point,°C
127
Autoignition, °C
> 620
Upper exp. limit, %
9.5
Lower exp. limit, %
0.9
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Containers may explode in the heat of a fire. Extinguishing media: For large fires, use water spray or fog. Do NOT get water inside containers. Do NOT use straight streams of water. Cool containers with flooding quantities of water until well after fire is out. For small fires, use dry chemical or carbon dioxide.
Fire potential
Slightly flammable. Combustible when exposed to heat or flame.
Hazards
When heated to decomposition it emits very toxic fumes of cyanide and nitrogen oxides. Reacts violently with amines, alcohol, bases and warm water causing fire and explosion hazards. Avoid strong oxidizers, water, acids, bases, amines, etc., cause foam and splatter. Avoid heating. Hazardous polymerization may occur. Concentrated alkaline compound such as sodium hydroxide or tertiary amines may cause run-away polymerization. Slow, not hazardous polymerization may occur above 235F.
Combustion products
Toxic oxides of nitrogen are produced during combustion of this material.
Health
3
 
Flammability
1
 
 
Reactivity
1
 

Health.
Exposure limit(s)
NIOSH REL: Ca See Appendix A OSHA PEL: C 0.02 ppm (0.14 mg/m3) IDLH Ca [2.5 ppm]
Carcinogin
I-2B, N-2
Poison_Class
2
Exposure effects
Acute exposures may produce headache, insomnia, euphoria, ataxia, anxiety neurosis with depression, paranoid tendencies, or impotence. No data were available to assess the teratogenic potential of this agent. <br>No data were available to assess the potential effects of exposure to this agent during pregnancy or lactation.
   Ingestion
Causes gastrointestinal tract irritation.
   Inhalation
May be fatal if inhaled. Causes respiratory tract irritation.
   Skin
Causes skin irritation.
   Eyes
Causes eye irritation.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. DO NOT use mouth-to-mouth respiration.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Get medical aid if symptoms occur.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
UN number
2078
Response guide
Hazard class
6.1
Packing Group
II
 
USCG CHRIS Code
TDI
 
HS Code
2929 10 10
 
IMO Pollution Category
C
IMO Hazard code
S/P