Toluene diisocyanate

  • Benzene, 1,3-diisocyanatomethyl
  • Diisocyanatotoluene
  • Isocyanic acid, methyl-m-phenylene ester
  • Methylphenylene isocyanate
  • Tolylene isocyanate
Formula
C9H6N2O2
Structure
Description
A clear colorless to pale yellow liquid with a pungent odor.
Uses
Used as a monomer in the preparation of polyurethane foams, elastomers and coatings, as a cross-linking agent for nylon-6, and as a hardener in polyurethane adhesives and finishes.

Registry Numbers and Inventories.
CAS
26471-62-5
EC (EINECS/ELINCS)
247-722-4
EC Index Number
615-006-00-4
EC Class
Carcinogenic Category 3; Very toxic; Irritant; Sensitising; Dangerous for the Environment
RTECS
NQ9490000
RTECS class
Tumorigen; Mutagen; Primary Irritant
UN (DOT)
2078
Beilstein/Gmelin
8399827
RCRA
U223
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C9H6N2O2
Formula mass
174.17
Melting point, °C
12 - 14
Boiling point, °C
251
Vapor pressure, mmHg
0.02
Vapor density (air=1)
6
Odor Threshold Odor threshold 2.10 ppm
Density
1.22 g/cm3 (20 C)

Hazards and Protection.
Storage
Store at toluene isocyanates indoors in unopened containers at 10 to 29 C. Protect from excessive heat and direct sunlight. Protect from contamination with water, alkali, strong bases, or atmospheric moisture.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Wear appropriate chemical protective clothing.
Respirators
Wear positive pressure self-contained breathing apparatus.
Small spills/leaks
Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personnel hazard. Use water spray to knock-down vapors.
Stability
Toluene diisocyanates do not present an explosion hazard. The DOT classifies toluene diisocyanates as materials that may explode from friction, shock, heat, or contamination.
Incompatibilities
Reaction with aniline may generate enough heat to ignite unreacted portion and surrounding materials Reaction with water liberates carbon dioxide.

Fire.
Flash Point,°C
127
Upper exp. limit, %
9.5
Lower exp. limit, %
0.9
Fire fighting
Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use alcohol foam, dry chemical or carbon dioxide. Use water spray to knock-down vapors.
Fire potential
This chemical is combustible.
Hazards
Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas.
Combustion products
Toxic oxides of nitrogen are produced during combustion of this material.
Health
3
 
Flammability
1
 
 
Reactivity
1
 

Health.
Carcinogin
I-2B, N-2, CP65
Exposure effects
Acute exposures may produce headache, insomnia, euphoria, ataxia, anxiety neurosis with depression, or paranoid tendencies.
   Ingestion
Inhalation of vapor or aerosol may produce vomiting and abdominal pain. Epigastric and substernal pain may be secondary to the paroxysmal or persistent cough associated with inhalation.
   Inhalation
Burning or irritation of the nose and throat, cough, laryngitis, chest pain, and asthmatic syndrome (chemical bronchitis with severe bronchospasm), sensation of oppression or constriction of the chest, bronchitis, emphysema and cor pulmonale may occur.
   Skin
Irritation and inflammation are common. Dermal absorption is low.
   Eyes
See Inhalation.

First aid
 
   Ingestion
DO NOT INDUCE VOMITING. Corrosive chemicals will destroy the membranes of the mouth, throat, and esophagus and, in addition, have a high risk of being aspirated into the victim's lungs during vomiting which increases the medical problems. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. Transport the victim IMMEDIATELY to a hospital.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Transport.
UN number
2078
Response guide
Hazard class
6.1
Packing Group
II
 
USCG CHRIS Code
TDI
 
Std. Transport #
4921575
 
IMO Chemical Code
17
IMO Pollution Category
C
IMO Hazard code
S/P