Tolylene 2,6-diisocyanate

  • 2-Methyl-1,3-phenylene diisocyanate
  • 2,6-Diisocyanatotoluene
  • 2,6-Toluylene diisocyanate
  • 2-Methyl-m-phenylene isocyanate
  • Toluene 2,6-diisocyanate
  • Isocyanic acid, 2-methyl-m-phenylene ester
Formula
C9H6N2O2
Structure
Description
Clear, colorless or pale yellow liquid with a characteristic pungent odor.
Uses
Peparation of polyurethane foams, elastomers and coatings, as a cross-linking agent for nylon-6, and as a hardener in polyurethane adhesives and finishes.

Registry Numbers and Inventories.
CAS
91-08-7
EC (EINECS/ELINCS)
202-039-0
EC Index Number
615-006-00-4
EC Class
Carcinogenic Category 3; Very toxic; Irritant; Sensitising; Dangerous for the Environment
R 26 36/37/38 40 42/43 52/53
S 23 36/37 45 61
RTECS
CZ6310000
RTECS class
Tumorigen; Mutagen; Human Data
UN (DOT)
2078
Beilstein/Gmelin
2211546
Beilstein Reference
4-13-00-00259
Swiss Giftliste 1
G-2083
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C9H6N2O2
Formula mass
174.16
Melting point, °C
13
Boiling point, °C
246 - 247
Vapor pressure, mmHg
0.02 (25 C)
Vapor density (air=1)
6.0
Saturation Concentration
Approx. 21 ppm at 20 C (calculated)
Odor Threshold Odor threshold 2.10 ppm
Density
1.22 g/cm3 (20 C)
Solubility in water
Insoluble
Refractive index
1.571 (20 C)
Partition coefficient, pKow
3.47
Heat of vaporization
48.6 kJ/mol

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Refrigerator (approx 4 C). Store protected from moisture.
D1A D2A D2B
Handling
Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Do not allow contact with water. Wash clothing before reuse. Keep from contact with moist air and steam.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, using the appropriate protective equipment. Provide ventilation. Do not get water inside containers.
Stability
Stable at room temperature in closed containers under normal storage and handling conditions.
Incompatibilities
Moisture, acids, alcohols, amines, strong bases, oxidizing agents.
Decomposition
Hydrogen cyanide, nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.

Fire.
Flash Point,°C
110
Autoignition, °C
> 549
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Contact with water forms corrosive vapors. Contact with water liberates highly flammable gases. Reacts with water, steam or acid to produce toxic and flammable vapors of hydrogen cyanide. Runoff from fire control or dilution water may cause pollution. Extinguishing media: Do NOT get water inside containers. For large fires, use water spray, fog or alcohol-resistant foam. Do NOT use straight streams of water. For small fires, use carbon dioxide, dry chemical, dry sand, or alcohol-resistant foam. Most foams will react with the material and release corrosive/toxic gases.
Fire potential
Slightly flammable. Toluene diisocyanates will burn but are difficult to ignite. Heat of reaction with aniline may ignite surrounding combustibles and material itself.
Hazards
When heated to decomposition, it emits toxic fumes of nitrogen oxides. Ventilation should be adequate. If polyurethane products are heated, protection against isocyanate release is necessary. Avoid decomposing heat.
Combustion products
Toxic oxides of nitrogen are produced during combustion of this material.
Health
2
 
Flammability
1
 
 
Reactivity
0
 

Health.
Exposure limit(s)
5 ppb TLV {36 µg/m3}
Carcinogin
I-2B, N-2
Poison_Class
2
Exposure effects
Effects may be delayed. Repeated or prolonged exposure may cause allergic reactions in sensitive individuals. Chronic overexposure to isocyanates has been reported to cause lung damage, including decreased lung fuction, which may be permanent.
   Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause liver and kidney damage. May cause cardiac disturbances. May cause central nervous system effects.
   Inhalation
Causes respiratory tract irritation. May cause liver and kidney damage. Central nervous system effects may include confusion, ataxia, vertigo, tinnitus, weakness, disorientation, lethargy, drowsiness, and finally coma. At high concentrations, isocyanates affect mucous membranes of the respiratory tract and may lead to fatal pulmonary edema. Exposure to low and often even unmeasurable isocyanate concentration results in sensitization. May cause cardiac damage. Can produce delayed pulmonary edema.
   Skin
Causes skin irritation. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. Organic isocyanates can cause local irritation and allergic reactions.
   Eyes
Produces irritation, characterized by a burning sensation, redness, tearing, inflammation, and possible corneal injury. Lachrymator. May cause chemical conjunctivitis.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Do NOT allow victim to rub or keep eyes closed.

Transport.
UN number
2078
Response guide
Hazard class
6.1
Packing Group
II
 
USCG CHRIS Code
TDJ
 
HS Code
2929 10 10