Treosulfan

  • Threosulphan
  • L-Threitol 1,4-bis(methanesulfonate)
  • 1,2,3,4-Butanetetrol, 1,4-dimethanesulfonate, [S-(R*,R*)]-
  • NSC 39069
Formula
C6H14O8S2
Structure
Description
Odorless white crystalline powder.
Uses
Antineoplastic

Registry Numbers and Inventories.
CAS
299-75-2
EC (EINECS/ELINCS)
206-081-0
RTECS
XO8500000
RTECS class
Tumorigen; Mutagen
Beilstein/Gmelin
1914305

Properties.
Formula
C6H14O8S2
Formula mass
278.32
Melting point, °C
123 - 124
Boiling point, °C
426
Solubility in water
Soluble
pKa/pKb
12.36 (pKa)
Partition coefficient, pKow
-2.78

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter).
Small spills/leaks
If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Stability
No data.

Fire.
Fire fighting
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.
Fire potential
This material is probably combustible.

Health.
Carcinogin
I-1, CP65
Exposure effects
   Ingestion
See inhalation.
   Inhalation
Symptoms of exposure to this compound include adrenal failure, transient marrow depression, mild pigmentation and minimal alopecia. Other symptoms include nausea, vomiting, stomatitis, jaundice, depression of leukocyte and platelet counts, agranulocytosis, mild exanthemata and Addison's syndrome.
   Skin
See inhalation.
   Eyes
See inhalation

First aid
 
   Ingestion
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Transport.