Triamterene

  • Ademine
  • Ademine
  • Diren
  • Ditak
  • Diurene
  • Dyren
Formula
C12H11N7
Structure
Description
Odorless yellow powder or crystalline solid. Almost tasteless at first and with a slightly bitter aftertaste. Acidified solutions give a blue fluorescence.
Uses
Medication (vet): diuretic & natriuretic agent.

Registry Numbers and Inventories.
CAS
396-01-0
EC (EINECS/ELINCS)
206-904-3
S 22 36/37
RTECS
UO3470000
RTECS class
Tumorigen; Drug; Mutagen; Human Data
Merck
12,9731
Beilstein/Gmelin
266723
Beilstein Reference
5-26-17-00447
Austrailia AICS
Listed
New Zealand
Listed
Korea ECL
Listed

Properties.
Formula
C12H11N7
Formula mass
253.27
Melting point, °C
316.1
Boiling point, °C
573
Vapor pressure, mmHg
4E-13 (25 C)
Solubility in water
Insoluble
pKa/pKb
7.70 (pKb)
Partition coefficient, pKow
0.98
Heat of fusion
53.9 kJ/mol
Heat of vaporization
85.9 kJ/mol

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter.
Small spills/leaks
If you spill this chemical, dampen the solid spill material with 5% ammonium hydroxide, then transfer the dampened material to a suitable container. Use absorbent paper dampened with 5% ammonium hydroxide to pick up any remaining material. Your contaminated clothing and the absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with 5% ammonium hydroxide followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Stability
Stable to temperature and light.
Incompatibilities
Incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides.

Fire.
Flash Point,°C
336
Fire fighting
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.
Fire potential
This material is probably combustible.

Health.
Exposure effects
weakness, areflexia, and fatigue may be noted secondary to hyperkalemia.
   Ingestion
Nausea and vomiting may be noted.
   Inhalation
Symptoms of exposure to this compound include gastrointestinal upset, dry mouth, weakness, tachycardia, hypotension, hyperkalemia, hypokalemia, rise in BUN and leukopenia. Other symptoms include hypersensitivity reactions including anaphylaxis, rash and photosensitivity, blood dyscrasias, liver damage, cardiac irregularities, azotemia, elevated creatinine, renal stones, acute interstitial nephritis (rare), jaundice and/or liver enzyme abnormalities, nausea, vomiting, diarrhea, thrombocytopenia, megaloblastic anemia, fatigue, dizziness and headache. Exposure can cause hyperuricemia, other disturbances in electrolyte metabolism, acidosis, allergic reactions and, rarely, thrombocytopenic purpura, fever and rigor. Muscle weakness may occur. Leg cramps may also occur.
   Skin
See inhalation.
   Eyes
See inhalation

First aid
 
   Ingestion
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. If symptoms (such as redness or irritation) develop, immediately transport the victim to a hospital.

Transport.