Triazolam

  • Novidorm
  • 8-Chloro-6-(2-chlorophenyl)-1-methyl-4H
  • Benzodiazepine
  • Clorazolam
  • Halcion
Formula
C17H12Cl2N4
Structure
Description
Tan crystals from 2-propanol.
Uses
Medication.

Registry Numbers and Inventories.
CAS
28911-01-5
EC (EINECS/ELINCS)
249-307-3
RTECS
XZ5472500
RTECS class
Drug; Reproductive Effector; Human Data
Merck
12,9734
Beilstein/Gmelin
1226643
New Zealand
Listed

Properties.
Formula
C17H12Cl2N4
Formula mass
343.21
Melting point, °C
233-235
Solubility in water
poorly soluble

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
No data.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
Reduced body temperature, respiratory depression, abnormally low blood pressure and low heart rate have been reported in overdose. ataxia, lethargy, sleepiness and slurred speech are common. Coma has been reported. Benzodiazepines may induce or worsen dyskinesia. Patients may be agitated (paradoxical effect) or disorientated, and may experience memory loss, confusion, and difficulty concentrating. Benzodiazepines are excreted in breast milk and may produce effects in the nursing infant. <br>Administration of benzodiazepines prior to delivery may produce signs of poisoning in the neonate. A condition called floppy infant syndrome, characterized by hypotonia that may last several days, may may occur following maternal diazepam use.
   Ingestion
Nausea and vomiting have been reported.
   Skin
Bullae have been reported.
   Eyes
For pure benzodiazepine ingestions, effects should be minimal, but may include prolonged dialation of the pupils, nystagmus, and divergence paralysis. Constriction of the pupil is also observed.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.