Trichlorobutanol

  • Acetone chloroform
  • Anhydrous chlorobutanol
  • 2-(Trichloromethyl)-2-propanol
  • 2,2,2-Trichloro-1,1-dimethylethanol
  • 1,1,1-Trichloro-tert-butyl alcohol
  • 1,1,1-Trichloro-2-methyl-2-propanol
Formula
C4H7Cl3O
Structure
Description
Colorless solid or liquid.
Uses
Plasticizer for cellulose esters and ethers, preservative for biological fluids, hypodermic soln and soln of alkaloids. Pharmaceutical aid (antimicrobial).

Registry Numbers and Inventories.
CAS
57-15-8
EC (EINECS/ELINCS)
200-317-6
R 22 36/37/38
S 26 36/37/39
RTECS
UC0175000
RTECS class
Drug; Mutagen; Reproductive Effector; Primary Irritant
Merck
13,2148
Beilstein/Gmelin
878167
Beilstein Reference
4-01-00-01629
EPA OPP
17501
Swiss Giftliste 1
G-2991
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C4H7Cl3O
Formula mass
177.46
Melting point, °C
78
Boiling point, °C
166
Vapor pressure, mmHg
0.6 (25 C)
Solubility in water
Insoluble
Refractive index
1.4339
pKa/pKb
12.87 (pKa)
Partition coefficient, pKow
2.07
Heat of vaporization
47.0 kJ/mol

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, using the appropriate protective equipment. Provide ventilation.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Oxidizing agents.
Decomposition
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, oxides of chlorine.

Fire.
Flash Point,°C
62
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Containers may explode when heated. Extinguishing media: Use agent most appropriate to extinguish fire. Cool containers with flooding quantities of water until well after fire is out. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Hazards
Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. Containers may explode when heated. Use agent most appropriate to extinguish fire.
Combustion products
During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Health
1
 
Flammability
0
 
 
Reactivity
0
 

Health.
Poison_Class
3
Exposure effects
   Ingestion
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
   Inhalation
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
   Skin
May cause skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.