Tricresyl phosphate

  • Tritolyl phosphate
  • Phosphoric acid tris(methylphenyl) ester
  • TCP
  • o-Cresyl phosphate
  • o-Tolyl phosphate
  • Tri-o-tolyl phosphate
Formula
C21H21O4P
Structure
Description
Colorless to pale yellow, oily, odorless liquid. Tricresyl phosphate (TCP) exists in three isomeric forms: ortho, meta, and para. The commercial product is a mixture of the three forms with as little of the highly toxic ortho-isomer (TOCP) as possible. The meta- and para-isomers are relatively inactive.
Uses
Plasticizer in lacquers & varnishes.

Registry Numbers and Inventories.
CAS
78-30-8
EC (EINECS/ELINCS)
201-103-5
EC Index Number
015-015-00-8
EC Class
Toxic; Dangerous for the Environment
R 39/23.24/25 51/53
S 20/21 45 28A 61
RTECS
TD0350000
RTECS class
Drug; Mutagen; Reproductive Effector
UN (DOT)
2574
Merck
12,9893
Beilstein/Gmelin
1892885
Beilstein Reference
4-06-00-01979
Swiss Giftliste 1
G-2085
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C21H21O4P
Formula mass
368.37
Melting point, °C
11
Boiling point, °C
410
Vapor pressure, mmHg
2E-6 (25 C)
Vapor density (air=1)
12.7
Odor Threshold Odor threshold Odorless
Density
1.1955 g/cm3 (20 C)
Solubility in water
Insoluble
Viscosity
144.67 cp (18 C)
Refractive index
1.56703 (20 C)
Dipole moment
2.87 (25 C)
Dielectric constant
6.73 (25 C)
pKa/pKb
7.00
Heat of vaporization
86.67 kJ/mol

Hazards and Protection.
Storage
Keep in a tightly closed galvanized steel container, stored in a cool, dry, ventilated area away from direct sunlight and open flames. Protect against physical damage. Isolate from any source of heat or ignition. Containers should be effectively sealed and clearly marked. Tricresyl phosphates should not be used in plastic articles which are likely to come into contact with foodstuffs or clothing.
D2A D1A
Handling
Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.
Protection
Skin: Wear impervious gloves. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A half facepiece particulate respirator (NIOSH type N95 or better filters) may be worn for up to ten times the exposure limit or the maximum use concentration specified by the appropriate regulatory agency or respirator supplier, whichever is lowest.. A full-face piece particulate respirator (NIOSH type N100 filters) may be worn up to 50 times the exposure limit, or the maximum use concentration specified by the appropriate regulatory agency, or respirator supplier, whichever is lowest. If oil particles (e.g. lubricants, cutting fluids, glycerine, etc.) are present, use a NIOSH type R or P filter. For emergencies or instances where the exposure levels are not known, use a full-facepiece positive-pressure, air-supplied respirator.
Small spills/leaks
Keep unnecessary and unprotected personnel from entering. Contain and recover liquid when possible. Collect liquid in an appropriate container or absorb with an inert material (e. g., vermiculite, dry sand, earth), and place in a chemical waste container. Do not use combustible materials, such as saw dust. Do not flush to sewer.
Stability
Stable under ordinary conditions of use and storage. Hydrolyzes slowly at room temperature under wet alkaline conditions.
Incompatibilities
Oxidizing agents.
Decomposition
Carbon monoxide, oxides of phosphorus, carbon dioxide.

Fire.
Flash Point,°C
225
Autoignition, °C
385
Lower exp. limit, %
0.4
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing media: Use carbon dioxide or dry chemical.
Fire potential
Slight risk when exposed to heat or flame.
Hazards
Containers may explode when heated. Runoff may pollute waterways.
Combustion products
During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Health
2
 
Flammability
1
 
 
Reactivity
0
 

Health.
Exposure limit(s)
TLV: ppm; 0.1 mg/m3 (skin) (ACGIH 1992-1993). OSHA PEL: TWA 0.1 mg/m3 NIOSH REL: TWA 0.1 mg/m3 skin NIOSH IDLH: 40 mg/m3
Poison_Class
1
Exposure effects
Repeated exposure may cause symptoms similar to those listed for acute effects. TCP inhibits cholinesterase. Neurologic damage can be severe and permanent.
   Ingestion
Causes irritation to the gastrointestinal tract. Symptoms may include nausea, vomiting and diarrhea. Breathing or swallowing large quantities may cause neurological disturbances which may progress to delayed neurotoxicity characterized by ataxia and tremors.
   Inhalation
Since TCP has low volatility, vapor inhalation is unlikely at normal temperatures; however, it may be a hazard if boiled. Mist or vapor can cause irritation to respiratory tract. May be absorbed into the bloodstream with symptoms similar to ingestion.
   Skin
Causes irritation to skin. Symptoms include redness, itching, and pain. May be absorbed through the skin without local irritant effects; symptoms similar to ingestion.
   Eyes
Causes irritation, redness, and pain. Rapid eye oscillation with dizziness may occur.

First aid
 
   Ingestion
Induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person. Consider gastric lavage if patients are comatose or at risk of convulsing. Since prolonged diarrhea may occur, avoid cathartic administration.
   Inhalation
Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
   Skin
Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.

Transport.
UN number
2574
Response guide
Hazard class
6.1
Packing Group
II
 
USCG CHRIS Code
TCO
 
Std. Transport #
4921682
 
IMO Chemical Code
17
IMO Pollution Category
A
IMO Hazard code
S/P