Trifluoroacetic acid

  • Perfluoroacetic acid
  • Trifluoroethanoic acid
  • 2,2,2-Trifluoroacetic acid
  • TFA
Formula
CF3COOH
Structure
Description
Colorless liquid. Pungent odor.

Registry Numbers and Inventories.
CAS
76-05-1
EC (EINECS/ELINCS)
200-929-3
EC Index Number
607-091-00-1
EC Class
Harmful; Corrosive; Dangerous for the Environment
R 20 35 52/53
S 9 26 27 28 45 61
RTECS
AJ9625000
RTECS class
Mutagen; Reproductive Effector
UN (DOT)
2699
Merck
12,9812
Beilstein/Gmelin
742035
Beilstein Reference
4-02-00-00458
Swiss Giftliste 1
G-7299
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C2HF3O2
Formula mass
114.02
Melting point, °C
-15
Boiling point, °C
71.8
Vapor pressure, mmHg
96 (25 C)
Vapor density (air=1)
3.9
Density
1.5351 g/cm3 (20 C)
Solubility in water
Miscible
Viscosity
0.74 cp (40 C)
Refractive index
1.28 (20 C)
Dielectric constant
42.1 (25 C)
pKa/pKb
0.67 (pKa)
Partition coefficient, pKow
1.24
Heat of vaporization
38.05 kJ/mol

Hazards and Protection.
Storage
Store in a cool, dry place. Keep container closed when not in use. Corrosives area. Keep containers tightly closed. Store in metal containers.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not ingest or inhale. Discard contaminated shoes. Keep away from strong bases and metals.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, using the appropriate protective equipment. Remove all sources of ignition. Provide ventilation.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Metals, oxidizing agents.
Decomposition
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, hydrogen fluoride.

Fire.
Flash Point,°C
-3
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Substance is noncombustible. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Extinguishing media: Do NOT get water inside containers. For small fires, use dry chemical, carbon dioxide, or water spray. For large fires, use dry chemical, carbon dioxide, alcohol-resistant foam, or water spray. Cool containers with flooding quantities of water until well after fire is out.
Fire potential
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.
Hazards
Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.
Combustion products
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.

Health.
Poison_Class
3
Exposure effects
   Ingestion
May cause severe and permanent damage to the digestive tract. Causes gastrointestinal tract burns. May cause severe gastrointestinal tract irritation with nausea, vomiting and possible burns.
   Inhalation
May cause severe irritation of the upper respiratory tract with pain, burns, and inflammation. Causes chemical burns to the respiratory tract.
   Skin
Causes skin burns.
   Eyes
May result in corneal injury. Contact with eyes may cause severe irritation, and possible eye burns.

First aid
 
   Ingestion
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Possible aspiration hazard. Get medical aid immediately.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. DO NOT use mouth-to-mouth respiration.
   Skin
Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. SPEEDY ACTION IS CRITICAL! Destroy contaminated shoes.
   Eyes
Get medical aid immediately. Do NOT allow victim to rub or keep eyes closed. Gently lift eyelids and flush continuously with water. Extensive irrigation is required (at least 30 minutes).

Transport.
UN number
2699
Response guide
Hazard class
8
Packing Group
I
 
HS Code
2915 90 80
 
Std. Transport #
4932391