Trimethoprim/Sulfamethoxazole

  • Abacin
  • APO sulfatrim
  • Bactramin
  • Bactrim
  • Bactromin
  • Benzenesulfonamide, 4-amino-N-(5-methyl-3-isoxazolyl)-, mixt. with 5-[(3,4,5-trimethoxyphenyl)methyl]-2,4-pyrimidinediamine
Formula
C14H18N4O3.C10H11N3O3S
Structure
Description
Paper disks of variable color.
Uses
Medication.

Registry Numbers and Inventories.
CAS
8064-90-2
RTECS
UV8240000
RTECS class
Drug; Human Data
Beilstein/Gmelin
5236098
Austrailia AICS
Listed

Properties.
Formula
C14H18N4O3*C10H11N3O3S
Formula mass
543.66
Melting point, °C
178 - 179
Density
1.406 g/cm3
Solubility in water
Insoluble

Hazards and Protection.
Storage
Keep in a cool, dry location. Keep containers sealed.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Not required under normal product usage.
Small spills/leaks
May be swept up and isposed of with normal laboratory waste.
Stability
Stable.
Incompatibilities
Strong oxidizing agents.
Decomposition
No data.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
coma, seizures, and hyperpyrexia occurred in the above pyrimethamine cases, occurring as early as 45 minutes postingestion. Acute exposure - neurologic: headache, depression, and hallucinations have been reported with therapeutic use of sulfonamides. Coma and seizures were reported following a large overdose of sulfasalazine in one patient. Tremor occurred in one patient following a fixed-dose combination of trimethoprim/sulfamethoxazole.
   Ingestion
Nausea and vomiting may occur.
   Inhalation
Pyrimethamine produced apnea and tachycardia, as well as cyanosis, during the first two hours.
   Skin
Itching and rash may occur.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.