Triparanol

  • Acosterina
  • Metasqualene
  • 2-p-Chlorophenyl-1-[p-(2-diethylaminoethoxy)phenyl]-1-p-tolylethanol
  • 1-(4-(2-Diethylaminoethoxy)phenyl)-1-p-tolyl-2-(4-chlorophenyl)ethanol
Formula
C27H32ClNO2
Structure
Description
Off-white powder.
Uses
Formerly used as a cholesterol lowering agent until it was found to produce cataracts. It was withdrawn in 1962.

Registry Numbers and Inventories.
CAS
78-41-1
EC (EINECS/ELINCS)
201-115-0
RTECS
KK2400000
RTECS class
Drug; Reproductive Effector
Merck
12,9867
Beilstein/Gmelin
2064866
Beilstein Reference
6-06

Properties.
Formula
C27H32ClNO2
Formula mass
438.01
Melting point, °C
102 - 104
Boiling point, °C
547
Vapor pressure, mmHg
9E-13 (25 C)
Solubility in water
Insoluble
pKa/pKb
4.38 (pKb)
Partition coefficient, pKow
6.72
Heat of vaporization
86.9 kJ/mol

Hazards and Protection.
Storage
Keep tightly closed. Store at 2-8 C
Protection
Compatible chemical-resistant gloves. Chemical safety goggles.
Respirators
Government approved respirator.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Incompatibilities
Oxidizing agents.
Decomposition
Carbon monoxide, Carbon dioxide, Nitrogen oxides, Hydrogen chloride gas.

Fire.
Flash Point,°C
285
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.
Health
2
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Harmful. Harmful if swallowed. Risk of serious damage to eyes.
   Ingestion
Harmful if swallowed.
   Inhalation
May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.
   Skin
May cause skin irritation. May be harmful if absorbed through the skin.
   Eyes
Causes severe eye irritation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.