Tripelennamine

  • Azaron
  • Benzoxale
  • 2-N-Benzyl-N',N'-dimethyl-n-2-pyridylethylenediamine
  • Dehistin
  • Cizaron
Formula
C16H21N3
Structure
Description
Oily liquid with an amine odor.
Uses
Sunburn treatment.

Registry Numbers and Inventories.
CAS
91-81-6
EC (EINECS/ELINCS)
202-100-1
RTECS
US2800000
RTECS class
Drug; Mutagen
Merck
12,9868
Beilstein/Gmelin
227074
Beilstein Reference
5-22-08-00378
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C16H21N3
Formula mass
255.36
Melting point, °C
191
Boiling point, °C
154 - 155 (0.2 torr)
Solubility in water
miscible
Refractive index
1.5502 (190 C)
pKa/pKb
4.93 (pKb)

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter.
Small spills/leaks
If you should spill this chemical, use absorbent paper to pick up all liquid spill material. Seal the absorbent paper, as well as any of your clothing which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Wash any surfaces you may have contaminated with a strong soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Stability
Slowly darkens on exposure to light.
Incompatibilities
Incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides.

Fire.
Fire fighting
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.
Fire potential
This material is probably combustible.

Health.
Exposure effects
Rapid heart rate is common. Elevated body temperature, abnormally low blood pressure, and elevated blood pressure have been reported. overdose may result in either CNS depression, including coma, or CNS stimulation, such as toxic psychosis. Subsequent seizures are not uncommon, especially in children. A higher incidence of seizures has been reported following pheniramine overdoses. Therapeutic use has been associated with acute dystonic reactions and dyskinesias. In general, there have been few reported teratogenic effects in humans, although animal studies have suggested that certain antihistamines have teratogenic potential. <br>Pyloric stenosis has occurred in infants following maternal use of antihistamines. <br>Small amounts of antihistamines are excreted in breast milk.
   Ingestion
Overdose may cause anticholinergic effects of ileus and diminished bowel sounds. Nausea, vomiting, and loss of appetite may occur .
   Inhalation
Pneumonitis, chest tightness, and wheezing have been reported.
   Skin
Skin may be flushed, warm and dry after overdose.
   Eyes
Anticholinergic effects, such as prolonged dialation of the pupils, nasal dryness and stuffiness, and mouth and throat dryness, can occur with overdose or therapeutic use.

First aid
 
   Ingestion
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Transport.