Tris

  • 2-Amino-2-(hydroxymethyl)-1,3-propanediol
  • Aminotris(hydroxymethyl)methane
  • Tris(hydroxymethyl)methylamine
  • Tromethanmin
  • Tutofusin tris
  • 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-
Formula
H2NC(CH2OH)3
Structure
Description
Crystalline mass or white, crystalline powder, slight characteristic amine odor, hygroscopic.
Uses
In synth of surface-active agents, vulcanization accelerators, pharmaceuticals: titrimetric standard, as emulsifying agent for cosmetic creams & lotions, mineral oil & paraffin wax emulsions, leather dressings, emulsifying agent for textile specialties, polishes, cleaning compd, so-called sol oils.

Registry Numbers and Inventories.
CAS
77-86-1
EC (EINECS/ELINCS)
201-064-4
EC Class
irritant
R 36/37/38
RTECS
TY2900000
RTECS class
Drug
Merck
12,9902
Beilstein/Gmelin
741883
Beilstein Reference
4-04-00-01903
EPA OPP
83901
Swiss Giftliste 1
G-7900
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C4H11NO3
Formula mass
121.14
Melting point, °C
131
Boiling point, °C
357
Vapor pressure, mmHg
2E-6 (25 C)
Density
1.328 g/cm3
Solubility in water
Very soluble
pKa/pKb
6.22 (pKb)
Partition coefficient, pKow
-1.38
Heat of vaporization
69.7 kJ/mol

Hazards and Protection.
Storage
Store in a cool, dry place. Keep away from acids. Keep containers tightly closed.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. Discard contaminated shoes.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal.
Disposal code
28
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Bases, oxidizing agents, acids, aldehydes, copper, brass, and aluminum.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.

Fire.
Flash Point,°C
170
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.

Health.
Poison_Class
-
Exposure effects
Prolonged or repeated skin contact may cause dermatitis.
   Ingestion
May cause severe gastrointestinal tract irritation with nausea, vomiting and possible burns.
   Inhalation
May cause irritation of the respiratory tract with burning pain in the nose and throat, coughing, wheezing, shortness of breath and pulmonary edema.
   Skin
May cause skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
USCG CHRIS Code
AHL
 
43 Misc. water solutions
HS Code
2922 19 80
 
IMO Chemical Code
18
IMO Pollution Category
III