Troglitazone

  • 2,4-Thiazolidinedione, 5-((4-((3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl) methoxy)phenyl)methyl)
  • CS-045
  • GR-92132X
  • 5-(4-(6-Hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl)thiazolidine-2,4-dione
  • Rezulin
  • Romglizone
Formula
C24H27NO5S
Structure
Description
Yellow solid.

Registry Numbers and Inventories.
CAS
97322-87-7
RTECS
XJ5813130
Merck
12,9898
Beilstein/Gmelin
4338399

Properties.
Formula
C24H27NO5S
Formula mass
441.55
Melting point, °C
184 - 186
Vapor pressure, mmHg
7.2E-18 (25 C)
Density
1.266 g/cm3 (20 C)
Solubility in water
Insoluble
pKa/pKb
6.34 (pKa)
Partition coefficient, pKow
4.99

Hazards and Protection.
Storage
This product should be stored at room temperature. It should be kept in a tightly closed container.
Protection
For spill clean up, wear suitable protective clothing, chemical resistant rubber gloves, rubber boots, and chemical safety goggles. Self contained breathing apparatus or NIOSH/MSHA approved respirator is recommended.
Small spills/leaks
Wipe up spill and place in sealed container and hold for disposal. Avoid raising dust. Ventilate the area and wash spill site after material has been removed.
Stability
This material is stable if stored as directed.

Fire.
Fire fighting
Extinguish with carbon dioxide, dry chemical powder, polymer foam, water spray. Use self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Health.
Exposure effects

First aid
 
   Ingestion
Remove dentures and clear mouth. If person is conscious, rinse mouth with water. Call physician or poison control immediately.
   Inhalation
Remove from exposure. If breathing is difficult, administer oxygen. If breathing stops, administer artificial respiration. Seek medical attention immediately.
   Skin
Wash with soap and water for 15 minutes. Remove contaminated clothing and shoes. Seek medical attention immediately.
   Eyes
Check for and remove contact lenses. Flush eyes with running water for at least 15 minutes separating eyelids. Seek medical attention immediately.

Transport.