Ubenimex

  • Bestatin
  • NK-421
  • N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine
  • 3-(R)-Amino-2-(S)-hydroxy-4-phenylbutanoyl-(S)-leucine
Formula
C16H24N2O4
Structure
Description
white powder
Uses
An aminopeptidase inhibitor used in combination with chemotherapeutics for the maintenance and enhancement of complete remission of acute non-lymphocytic leukemia in adults.

Registry Numbers and Inventories.
CAS
58970-76-6
EC (EINECS/ELINCS)
261-529-2
22 24/25
RTECS
OH2915000
RTECS class
Drug; Reproductive Effector; Natural Product
Merck
12,9973
Beilstein/Gmelin
4704312
Beilstein Reference
6-14

Properties.
Formula
C16H24N2O4
Formula mass
308.38
Melting point, °C
231 - 234
Vapor pressure, mmHg
2E-15 (25 C)
Solubility in water
Soluble
pKa/pKb
3.60 (pKa)
Heat of vaporization
94.5 kJ/mol

Hazards and Protection.
Storage
Keep tightly closed.
Protection
Protective gloves. Chemical safety goggles.
Respirators
Wear dust mask.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, Carbon dioxide, Nitrogen oxides, Hydrogen chloride gas.

Fire.
Flash Point,°C
320
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.
Health
1
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
The chemical, physical, and toxicological properties of this product have not been thoroughly investigated. Exercise due care.
   Ingestion
May be harmful if swallowed.
   Inhalation
May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.
   Skin
May cause skin irritation. May be harmful if absorbed through the skin.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
   Skin
In case of contact, immediately wash skin with soap and copious amounts of water.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.