Valproic acid

  • Di-n-propylacetic acid
  • Mylproin
  • 2-Propylpentanoic acid
  • 2-Propylvaleric acid
Formula
C8H16O2
Structure
Description
Clear colorless liquid.
Uses
Medication.

Registry Numbers and Inventories.
CAS
99-66-1
EC (EINECS/ELINCS)
202-777-3
EC Class
harmful, irritant
R 22 34
S 26 36/37/39 45
RTECS
YV7875000
RTECS class
Drug; Reproductive Effector; Human Data
UN (DOT)
3265
Merck
12,10049
Beilstein/Gmelin
1750447
Beilstein Reference
3-02-00-00807
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C8H16O2
Formula mass
144.21
Boiling point, °C
220
Vapor pressure, mmHg
0.044 (25 C)
Vapor density (air=1)
4.97
Density
0.9215 g/cm3 (0 C)
Solubility in water
Soluble
Refractive index
1.4236 (20 C)
pKa/pKb
4.82 (pKa)
Partition coefficient, pKow
2.75
Heat of vaporization
50.3 kJ/mol

Hazards and Protection.
Storage
Keep containers tightly closed. Store in a cool, dry area away from incompatible substances.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale. Do not breathe vapors.
Protection
Eyes: Wear safety glasses and chemical goggles if splashing is possible. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Cover with sand, dry lime or soda ash and place in a closed container for disposal. Provide ventilation.
Disposal code
4
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Oxidizing agents, reducing agents, bases.
Decomposition
Carbon monoxide, carbon dioxide, acrid smoke and fumes.

Fire.
Flash Point,°C
111
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Water may be ineffective. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Fire potential
This chemical is combustible.
Hazards
When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
2
 
Flammability
1
 
 
Reactivity
0
 

Health.
Exposure effects
May cause reproductive and fetal effects.
   Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause liver damage. May be harmful if swallowed. May cause central nervous system depression. May cause stupor, drowsiness, unconsiousness, or coma (if ingested in large amounts). Causes changes in exocrine pancreas and sleep disturbances.
   Inhalation
Causes chemical burns to the respiratory tract. May cause burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting.
   Skin
May cause severe irritation and possible burns.
   Eyes
Contact with eyes may cause severe irritation, and possible eye burns.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. Do not use mouth-to-mouth respiration if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.
   Skin
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
3265
Response guide
Hazard class
8
Packing Group
I; II; III
 
4. Organic acids
HS Code
2915 90 80