Vanillic acid diethylamide

  • Ethamivan
  • N,N-Diethylvanillamide
  • N,N-Diethyl-4-hydroxy-3-methoxybenzamide
  • 3-Methoxy-4-hydroxybenzoic acid diethylamide
Formula
C12H17NO3
Structure
Description
Obtained by oxidation of vanillin.
Uses
A central nervous system stimulant and analeptic, used as a respiratory stimulant, administered intravenously.

Registry Numbers and Inventories.
CAS
304-84-7
EC (EINECS/ELINCS)
206-157-3
36/37/39 45
RTECS
YW5250000
RTECS class
Drug
UN (DOT)
2811
Merck
12,3765
Beilstein/Gmelin
2694478
Beilstein Reference
4-10-00-01481
Swiss Giftliste 1
G-9091

Properties.
Formula
C12H17NO3
Formula mass
223.27
Melting point, °C
96
Boiling point, °C
401
Vapor pressure, mmHg
5E-7 (25 C)
Solubility in water
Insoluble
pKa/pKb
8.73 (pKa)
Heat of vaporization
67.8 kJ/mol

Hazards and Protection.
Protection
Wear appropriate government approved respirator, chemical-resistant gloves, safety goggles, other protective clothing.
Respirators
Wear positive pressure self-contained breathing apparatus (SCBA).
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Decomposition
Carbon monoxide, Carbon dioxide, Nitrogen oxides.

Fire.
Flash Point,°C
197
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Fire potential
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.
Hazards
Contact with metals may evolve flammable hydrogen gas.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.

Health.
Poison_Class
3
Exposure effects
Toxic. Toxic by inhalation, in contact with skin and if swallowed. Target organ(s): Central nervous system.
   Ingestion
See Inhalation.
   Inhalation
TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Effects of contact or inhalation may be delayed.
   Skin
Contact with molten substance may cause severe burns to skin and eyes. See Inhalation.
   Eyes
See Inhalation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.
UN number
2811
Response guide
Hazard class
6.1
Packing Group
III