Vanillin

  • 4-Hydroxy-3-methoxybenzaldehyde
  • Vanillaldehyde
  • Vanillic aldehyde
  • 4-Formyl-2-methoxyphenol
  • Rhovanil
  • p-Hydroxy-m-methoxybenzaldehyde
Formula
(CH3O)(OH)C6H3CHO
Structure
Description
White or very slightly yellow needles.
Uses
Flavoring agent in galenicals, in perfumery, reagent in analytical chemistry, pharmaceutic aid (flavor).

Registry Numbers and Inventories.
CAS
121-33-5
EC (EINECS/ELINCS)
204-465-2
S 22 36/37
RTECS
YW5775000
RTECS class
Mutagen; Reproductive Effector; Natural Product
Merck
12,10069
Beilstein/Gmelin
472792
Beilstein Reference
4-08-00-01763
EPA OPP
115801
Swiss Giftliste 1
G-3046
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C8H8O3
Formula mass
152.15
Melting point, °C
82
Boiling point, °C
285
Vapor pressure, mmHg
0.0019 (25 C)
Vapor density (air=1)
5.2
Density
1.056 g/cm3 (20 C)
Solubility in water
10 g/L
Refractive index
1.555
pKa/pKb
7.78 (pKa)
Partition coefficient, pKow
1.37
Heat of vaporization
54.3 kJ/mol
Heat of combustion
-1850 kJ/mol

Hazards and Protection.
Storage
Store in a cool, dry place. Store protected from moisture. Store protected from light.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Store protected from light.
Protection
Eyes: Wear safety glasses and chemical goggles if splashing is possible. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Provide ventilation.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents, strong bases, light, air, strong reducing agents, moisture, bromine, perchloric acid, potassium t-butoxide, t-chlorobenzene and sodium hydroxide, formic acid and thallium nitrate.
Decomposition
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Flash Point,°C
118
Autoignition, °C
> 400
Upper exp. limit, %
8.8
Lower exp. limit, %
1.2
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use agent most appropriate to extinguish fire.
Fire potential
Flammability properties of some synthetic fragrant substances and intermediate products.
Health
1
 
Flammability
1
 
 
Reactivity
0
 

Health.
Exposure limit(s)
OSHA Permissible Exposure Limit (PEL): 15 mg/m3 total dust, 5 mg/m3 respirable fraction for nuisance dusts.
Poison_Class
4
Exposure effects
   Ingestion
May cause irritation of the digestive tract.
   Inhalation
No hazard expected in normal industrial use. Dust is irritating to the respiratory tract.
   Skin
Dust may cause mechanical irritation. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. Low hazard for usual industrial handling.
   Eyes
Dust may cause mechanical irritation. Low hazard for normal industrial handling.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Treat symptomatically and supportively. Get medical aid if irritation or symptoms occur.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear.
   Skin
Get medical aid if irritation develops or persists. Wash clothing before reuse. Flush skin with plenty of soap and water.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
HS Code
2912 41 00