(+/-)-Verapamil hydrochloride

  • Calan
  • Cordilox
  • D-365 hydrochloride
  • Finoptin
  • Iproveratril hydrochloride
  • Valeronitrile, 5-((3,4-dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropyl-, monohydrochloride
Formula
C27H38N2O4.HCl
Structure
Description
odorless white powder
Uses
Blood pressure medication.

Registry Numbers and Inventories.
CAS
152-11-4
EC (EINECS/ELINCS)
205-800-5
RTECS
YV8320000
RTECS class
Drug; Mutagen; Reproductive Effector; Human Data
Beilstein/Gmelin
3647093
Austrailia AICS
Listed
New Zealand
Listed

Properties.
Formula
C27H38N2O4*ClH
Formula mass
491.07
Melting point, °C
142 - 145
Partition coefficient, pKow
0.58

Hazards and Protection.
Storage
Store in a tightly closed container. Refrigerator (approx 4 C).
Handling
Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.
Protection
Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container.
Stability
Stable under normal shipping and handling conditions.
Incompatibilities
Bases.
Decomposition
Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.

Health.
Exposure effects
   Ingestion
May cause irritation of the digestive tract. Poison by ingestion.
   Inhalation
May cause respiratory tract irritation. Toxic if inhaled. May cause nausea, dizziness, and headache.
   Skin
May cause skin irritation. Toxic in contact with skin.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
Get medical aid immediately. Wash mouth out with water.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
   Skin
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.