Verapamil

  • Dilacoran
Formula
C27H38N2O4
Structure
Description
Viscous, pale yellow oil.
Uses
calcium channel blocker

Registry Numbers and Inventories.
CAS
52-53-9
EC (EINECS/ELINCS)
200-145-1
RTECS
YV8300000
RTECS class
Drug; Reproductive Effector; Human Data
Merck
12,10083
Beilstein/Gmelin
2825000
Austrailia AICS
Listed
New Zealand
Listed
Korea ECL
Listed

Properties.
Formula
C27H38N2O4
Formula mass
454.61
Boiling point, °C
232 - 235 (0.01 torr)
Solubility in water
practically insoluble
Refractive index
1.5448 (25 C)

Hazards and Protection.
Storage
Store in a cool, dry location in a tightly closed container.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Latex gloves, chemical safety goggles and disposable protective clothing.
Respirators
A NIOSH approved respirator should be available.
Small spills/leaks
While wearing recommended personal protective equipment, absorb liquid with paper and place in a container for disposal.
Stability
Stable at normal temperatures and pressures.

Fire.
Fire fighting
Wear self contained breathing apparatus and protective clothing. Use water spray, carbon dioxide, dry chemical or foam to extinguish fire.
Combustion products
May emit toxic fumes.

Health.
Exposure effects
CNS depression, secondary to hemodynamic instability occurs following significant overdose. Effects may include drowsiness, confusion, and coma. Cerebral infarction has been reported.
   Ingestion
Nausea and vomiting occur frequently. Ileus can also occur. Concretions from sustained-release dosage forms have been found at autopsy. Bowel infarction has also been reported.
   Inhalation
Respiratory effects are uncommon but noncardiogenic pulmonary edema, may occur following significant overdose.
   Skin
Causes irritation. Flushing is common with nifedipine.
   Eyes
Causes irritation.

First aid
 
   Ingestion
Flush mouth with water. See medical assistance.
   Inhalation
Remove to fresh air.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Flush with water and seek medical assistance.

Transport.