Vinblastine sulfate

  • Vincaleucoblastine sulfate
  • 2H-3,7-Methanoazacycloundecino[5,4-b]indole, vincaleukoblastine deriv.
  • 1H-Indolizino[8,1-cd]carbazole, vincaleukoblastine deriv.
Formula
C46H58N4O9.H2O4S
Structure
Description
An anticancer drug. White to slightly yellow crystalline powder.
Uses
Pharmaceuticals

Registry Numbers and Inventories.
CAS
143-67-9
EC (EINECS/ELINCS)
205-606-0
RTECS
YY8400000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data
Beilstein/Gmelin
3659812
Beilstein Reference
4-26-00-03167
Austrailia AICS
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C46H58N4O9*H2O4S
Formula mass
909.16
Melting point, °C
284 - 285
Solubility in water
Insoluble
Partition coefficient, pKow
2.04

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a dry area. Refrigerate at 4C.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Wear appropriate safety goggles, protective clothing and gloves.
Respirators
Wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter.
Small spills/leaks
If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Stability
No data.
Incompatibilities
Sensitive to light, hydrolysis, oxidation, and heat.

Fire.
Fire fighting
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.

Health.
Exposure effects
   Ingestion
Harmful if swallowed.
   Inhalation
Causes irritation. May cause harm to the unborn child.
   Skin
Causes irritation.
   Eyes
May cause irreversible eye injury.

First aid
 
   Ingestion
DO NOT INDUCE VOMITING. Strychnine is an exceptionally toxic poison but inducing vomiting may cause a seizure. IMMEDIATELY call a hospital or poison control center and locate activated charcoal, egg whites, or milk in case the medical advisor recommends administering one of them. If advice from a physician is not readily available and the victim is conscious and not convulsing, give the victim a glass of activated charcoal slurry in water or, if this is not available, a glass of milk, or beaten egg whites and IMMEDIATELY transport victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, assure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Transport.