Vincristine

  • LCR
  • Leurocristine
  • 22-Oxovincaleukoblastine
  • VCR
  • Vincrystine
  • Vinkristin
Formula
C46H56N4O10
Structure
Description
A white crystalline solid.
Uses
Medication (vet).

Registry Numbers and Inventories.
CAS
57-22-7
EC (EINECS/ELINCS)
200-318-1
RTECS
OH6300000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data; Natural Product; Primary Irritant
Merck
12,10124
Beilstein/Gmelin
605173
Japan ENCS (MITI)
Listed

Properties.
Formula
C46H56N4O10
Formula mass
824.97
Melting point, °C
218-220
Solubility in water
Insoluble
pKa/pKb
6.36 (pKb)

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter.
Small spills/leaks
STORAGE PRECAUTIONS: You should store this material in a refrigerator.
Stability
Sterile solution in either h2o or physiological saline stored in refrigerator for up to 2 wk without significant loss of potency.

Fire.
Fire fighting
Fires involving this compound should be controlled with a dry chemical, carbon dioxide or Halon extinguisher.

Health.
Exposure effects
Fever may occur following an overdose. peripheral neuropathies, progressive weakness, loss of deep tendon reflexes, headache, confusion, hallucinations, delirium, insomnia, generalized pain of face, jaw, and neck, coma, seizures, optic neuropathy, and death have been reported.
   Ingestion
Nausea/vomiting usually occur within 24 hours. Paralytic ileus and constipation may occur. Colicky abdominal pain has been reported.
   Skin
Alopecia and skin rash have been reported.

First aid
 
   Ingestion
DO NOT INDUCE VOMITING. Strychnine is an exceptionally toxic poison but inducing vomiting may cause a seizure. IMMEDIATELY call a hospital or poison control center and locate activated charcoal, egg whites, or milk in case the medical advisor recommends administering one of them. If advice from a physician is not readily available and the victim is conscious and not convulsing, give the victim a glass of activated charcoal slurry in water or, if this is not available, a glass of milk, or beaten egg whites and IMMEDIATELY transport victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, assure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Transport.