Vitamin B1

  • 3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methylthiazolium chloride
  • Aneurine
  • Thiamin
  • Thiamine, chloride
  • Thiazolium, 3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl- chloride
Formula
C12H17N4OS.Cl
Structure
Description
Off-white powder with a characteristic odor.
Uses
Prevention and treatment of vitamin B1 deficiency.

Registry Numbers and Inventories.
CAS
59-43-8
EC (EINECS/ELINCS)
200-425-3
RTECS
XI6550000
RTECS class
Drug; Reproductive Effector; Human Data
Merck
12,9430
Beilstein/Gmelin
3581326
Beilstein Reference
4-27-00-01764
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C12H17N4OS.Cl
Formula mass
300.81
Melting point, °C
128 - 129
Boiling point, °C
122-128 (0.03 torr):
Vapor pressure, mmHg
Negliglible.
Vapor density (air=1)
10.4
Density
1.43 g/cm3
Solubility in water
Slightly soluble.

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Wash clothing before reuse.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Clean up spills immediately. Use protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Nitrogen oxides, carbon monoxide, oxides of sulfur, irritating and toxic fumes and gases, carbon dioxide, nitrogen.

Fire.
Flash Point,°C
100
Autoignition, °C
365
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.
Health
1
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
   Ingestion
Nausea, vomiting, abdominal pain, and diarrhea are common, especially following ingestion of multiple vitamins with iron (see iron management).
   Inhalation
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Low hazard for usual industrial handling.
   Skin
May cause skin irritation. May cause dermatitis.
   Eyes
May cause irritation.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.