Warfarin sodium

  • Zoocoumarin sodium salt
  • Coumadin sodium
  • Coumarin, 3-(a-acetonylbenzyl)-4-hydroxy-, sodium salt
  • 2H-1-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)-, sodium salt
Formula
C19H16O4 . Na
Structure
Description
Slightly bitter crystalline powder. Odorless.
Uses
Rodenticide.

Registry Numbers and Inventories.
CAS
129-06-6
EC (EINECS/ELINCS)
204-929-4
RTECS
GN4725000
RTECS class
Drug; Mutagen; Reproductive Effector; Human Data
Beilstein/Gmelin
5469050
EPA OPP
86003
Canada DSL/NDSL
NDSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed

Properties.
Formula
C19H16O4 . Na
Formula mass
331.32

Hazards and Protection.
Storage
Store at away from heat and open flame. Do not store near feeds and foodstuffs and keep away from children, domestic animals, pets, or wildlife.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Use safety glasses and full face shield, Neoprene or Tyvek gloves, apron, boots and/or whole body suit.
Respirators
Wear NIOSH/<SHA pproved air purifying respirator/positive pressure air-supplied respirator.
Small spills/leaks
Do not touch spilled material; stop leak if you can do it without risk. Use water spray to reduce vapors. For small spills, take up with sand or other noncombustible absorbent material and place into containers for later disposal. For small dry spills, with clean shovel place material into clean, dry container and cover; move containers from spill area. For large spills, dike far ahead of spill for later disposal.
Stability
Contact with strong oxidizers may cause fires and explosions.

Fire.
Fire fighting
Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Wear positive pressure breathing apparatus and special protective clothing. Remove and isolate contaminated clothing at the site. Move container from fire area if you can do it without risk. Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material. Extinguish fires with dry chemical, carbon dioxide, water spray, fog, or foam.
Hazards
When heated to decomposition, it emits toxic fumes of sodium oxide.

Health.
Exposure effects
Warfarin has been established as a human teratogen, because it causes birth defects in the offspring of women receiving clinical doses of the compound during any trimester of pregnancy.
   Ingestion
See inhalation.
   Inhalation
This material is highly toxic orally in humans. Long term overexposure may cause susceptibility to bruising, longer blod clotting times, blood in the stool and urine. Blotches on the skin.
   Skin
See inhalation.
   Eyes
See inhalation

First aid
 
   Ingestion
Give water and induce vomiting. Never give anthing to an unconscious person. Obtain medical attention.
   Inhalation
Remove to fresh air. Give CPR and/or oxygen if required.
   Skin
Wash with soap and water.
   Eyes
Flush with water for 15 minutes.

Transport.