Warfarin

  • 4-Hydroxy-3-(3-oxo-1-phenylbutyl)coumarin
  • 3-(alpha-Acetonylbenzyl)-4-hydroxycoumarin
  • 2H-1-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)
Formula
C19H16O4
Structure
Description
Colorless crystals.
Uses
Rodenticide for norway rats & for house mice.

Registry Numbers and Inventories.
CAS
81-81-2
EC (EINECS/ELINCS)
201-377-6
EC Index Number
607-056-00-0
EC Class
Toxic for reproduction Category 1; Toxic; Dangerous for the Environment
RTECS
GN4550000
RTECS class
Agricultural Chemical and Pesticide; Reproductive Effector; Human Data
UN (DOT)
3027
Merck
12,10174
Beilstein/Gmelin
1293536
Beilstein Reference
5-18-04-00162
RCRA
P001
EPA OPP
86002
Swiss Giftliste 1
G-1444
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C19H16O4
Formula mass
308.33
Melting point, °C
167 - 168
Boiling point, °C
515
Vapor pressure, mmHg
2E-11 (25 C)
Vapor density (air=1)
10.6
Solubility in water
20 mg/L
pKa/pKb
4.50 (pKa)
Partition coefficient, pKow
2.52
Heat of vaporization
82.9 kJ/mol

Hazards and Protection.
Storage
Store at away from heat and open flame. Do not store near feeds and foodstuffs and keep away from children, domestic animals, pets, or wildlife.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Wear appropriate protective gloves, clothing and goggles.
Respirators
Wear positive pressure self-contained breathing apparatus (SCBA).
Small spills/leaks
Do not touch spilled material. Eating and smoking should not be permitted in areas where it is handled, processed or stored. For small spills: sweep onto paper or other suitable material. Place in an appropriate container and burn in a safe place. Large quantities may be destroyed by dissolving in a flammable solvent (e.g., alcohol) and atomizing in a combustion chamber.
Stability
Contact with strong oxidizers may cause fires and explosions.
Incompatibilities
Incompatible with the following: Strong oxidizers.

Fire.
Flash Point,°C
188
Fire fighting
(Non-Specific -- Poison B Solid) Wear full protective clothing and self-contained breathing apparatus.(Non-Specific -- Poison B Solid) Extinguish fire using agent suitable for type of surrounding fire. Use alcohol foam, carbon dioxide, or dry chemical.
Fire potential
Contact with strong oxidizers may cause fires and explosions.
Hazards
Contact with strong oxidizers may cause fires and explosions. Toxic gases and vapors (e.g., carbon monoxide) may be released in heating to decomposition. Avoid strong oxidizers.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.

Health.
Exposure limit(s)
TLV: ppm; 0.1 mg/m3 (as TWA) (ACGIH 1991-1992). OSHA PEL: TWA 0.1 mg/m3 NIOSH REL: TWA 0.1 mg/m3 NIOSH IDLH: 100 mg/m3
Poison_Class
2
Exposure effects
Intracranial hemorrhage and hematomyelia may occur following warfarin therapy. The use of warfarin during pregnancy has been associated with teratogenic effects. <br>Fetal intraventricular hemorrhage has been reported following maternal ingestion of warfarin. <br>Craniofacial, musculoskeletal, skin, eye, gastrointestinal, and cardiovascular developmental abnormalities have been observed in the offspring of women administered warfarin sodium during pregnancy. <br>Intrauterine fetal demise, intrauterine growth retardation, and hemorrhagic disease of the newborn have been reported following administration of warfarin sodium to pregnant women.
   Ingestion
Abdominal pain, vomiting, gastrointestinal bleeding, hemoptysis, and bloody or melenotic stools may occur.
   Inhalation
Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Effects of contact or inhalation may be delayed.
   Skin
Warfarin may be absorbed through the skin and cause systemic poisoning.
   Eyes
See Inhalation.

First aid
 
   Ingestion
Seek medical assistance.
   Inhalation
Move victim to fresh air. Apply artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult.
   Skin
Remove and isolate contaminated clothing and shoes. Remove material from skin immediately. Immediately flush with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin.
   Eyes
Immediately flush with running water for at least 20 minutes.

Transport.
UN number
3027
Response guide
Hazard class
6.1
Packing Group
I; II; III